2-Bromo-4-Quinolinecarboxylic Acid CAS 15733-87-6

Product Overview

High-purity 2-bromo-4-quinolinecarboxylic acid is a versatile brominated heterocyclic building block for pharmaceutical and materials research. The strategic positioning of bromine (C-2) and carboxyl (C-4) groups enables diverse functionalization via cross-coupling, metalation, or condensation reactions.

Product Information

IUPAC Name: 2-Bromoquinoline-4-carboxylic acid
Synonyms: 2-Bromo-4-quinolinecarboxylate; 2-Bromochinolin-4-carbonsäure
CAS Number: 15733-87-6
Molecular Formula: C₁₀H₆BrNO₂
Molecular Weight: 252.07 g/mol
Structural Features:
- Bromo-substitution at C-2 enables cross-coupling
- Carboxyl group at C-4 for amide/ester formation
- Aromatic quinoline core for π-stacking interactions

Specifications

Parameter	Specification
Appearance	Off-white to yellow crystalline powder
Purity (HPLC)	≥98% (standard), ≥99% available
Melting Point	210–215°C (dec.)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Halogen Content	30.5–32.5% (theory: 31.7%)

Physical & Chemical Properties

Solubility:
✔ Soluble: DMSO (50 mg/mL), 1M NaOH
✔ Partially soluble: Hot methanol/ethanol
✘ Insoluble: Water, hexane, ether
Spectroscopic Data:
- UV (MeOH): λ_max 254 nm, 310 nm
- IR (KBr): 1685 cm^-1 (C=O), 1580 cm^-1 (quinoline C=C)
Stability:
- Stable at RT for 12 months in sealed containers
- Sensitive to prolonged UV exposure

Applications

Pharmaceutical Intermediates

Key precursor for:
✔ Quinoline-based antimicrobial agents
✔ Kinase inhibitor scaffolds
✔ Antimalarial drug analogs

Chemical Synthesis

Suzuki-Miyaura coupling substrate
Lithiation/functionalization at C-3 position
Dirhodium catalyst ligand

Materials Science

Building block for OLED materials
Coordination polymers via carboxyl group

Packaging & Supply

Standard Packaging

Quantity	Packaging	Special Features
100 g	Aluminum foil bag	Oxygen barrier
500 g	Aluminum foil bag	Oxygen barrier
1 Kg	HDPE bottle	Desiccant included
5 Kg	Fiber drum	UN-certified

Special Options

Custom concentrations (0.1–1M solutions in DMSO/DMF)
Milligrams to kilogram-scale production
Isotope-labeled versions (¹³C/¹⁵N)

Storage & Handling

Storage:
- 2–8°C in original packaging
- Argon atmosphere recommended for long-term storage
Handling:
- Use nitrile gloves and dust mask
- Avoid contact with strong oxidizers

Quality Documentation

Certificate of Analysis:
- Batch-specific HPLC, NMR (¹H/¹³C), MS
- Elemental analysis report
Regulatory Files:
- SDS (OSHA/GHS compliant)
- Reach registration dossier

Appearance	Off-white to yellow crystalline powder
Purity (HPLC)	99%min
Water Content (KF)	0.5%max
Heavy Metals	≤20 ppm
Packing	100g, 500g, 1Kg, 5kg, 25kg, based on customer's order
MOQ	Flexible MOQ available from gram to kilogram scale.
Supply Capacibility	It is our standard product which is in stock and can be shipped within 3–7 working days. Larger quantities available upon request

Technical Data