TPN171 CAS .1229018-87-4

TPN171 is a highly potent PDE5 inhibitor, demonstrating sub-nanomolar activity against PDE5 along with excellent selectivity over PDE6. It is currently under clinical development for the treatment of pulmonary arterial hypertension (PAH). In preclinical studies, TPN171 has shown a longer duration of action compared to sildenafil, supporting its potential for once-daily oral administration in clinical use.

Technical Data

Related CAS	1229018-87-4 (free base) 2258665-03-9 (acetate) 2258665-04-0 (mesylate) 2258665-07-3 (HCl)
Synonym	TPN171; TPN-171; TPN 171;
Chemical Name	N-(3-(5,6-Diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide
Chemical Formula	C24H35N5O3
Molecular Weight	441.58
Appearance	White powder
Purity	99%min
Storage Condition	Store in a sealed container at room temperature.
Shelf Life	>3 years if stored properly
Supply Capacity	This product is supported by kilogram-scale production capacity, delivering ≥99% purity (HPLC). We maintain regular production and buffer stock, enabling reliable supply and faster delivery for ongoing customer needs.

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