Product Overview
2-Chloroquinoline-4-carboxylic acid is a versatile heterocyclic intermediate featuring both chloro and carboxyl functionalities on a quinoline scaffold. This bifunctional structure enables broad applicability in pharmaceutical synthesis and advanced materials development.
The compound is particularly valued for its performance in nucleophilic substitution and palladium-catalyzed cross-coupling reactions, making it a reliable building block for complex molecule construction.
Key Specifications
| Item | Specification |
|---|---|
| Appearance | White to pale yellow crystalline powder |
| Purity | ≥98% (standard) / ≥99% (high purity grade) |
| Molecular Formula | C₁₀H₆ClNO₂ |
| Molecular Weight | 207.61 g/mol |
| Melting Point | 225–230°C (decomp.) |
| Water Content | ≤0.5% (KF) |
| Heavy Metals | ≤10 ppm |
Structural Features
- C-2 chloro substitution: Reactive site for cross-coupling
- C-4 carboxyl group: Enables downstream derivatization
- Quinoline core: Extended π-conjugated system
Applications
This product serves as a high-value intermediate across multiple domains:
Pharmaceutical Development
- Antimalarial quinoline derivatives
- Kinase inhibitor intermediates
- Antibacterial agent synthesis
Chemical Synthesis
- Substrate for Buchwald–Hartwig amination
- Intermediate for Pd-catalyzed cross-coupling reactions
- Ligand precursor for metal complex formation
Advanced Materials
- Functional unit in Organic Light-Emitting Diodes
- Building block for coordination polymers
Supply Capability
Typically available from stock and ready for immediate shipment, with scalable production capacity to support larger-volume demands.
- Supply range: 100 g to 1000 kg
- Minimum order quantity: 100 g (no milligram-scale supply available)
- Stable batch-to-batch quality
- Reliable lead times for repeat and bulk orders
Packaging & Sizes
Available Sizes
100 g / 500 g / 1 kg / 5 kg / 25 kg
(Customized based on order quantity)
Packaging Options
- Amber glass vials (small scale, light protection)
- Aluminum foil bags (moisture barrier)
- HDPE bottles with desiccants
- UN-certified fiber drums (bulk quantities)
Stability & Storage
- Stable for ≥24 months under recommended conditions
- Store in a tightly sealed container
- Protect from moisture and light
- Desiccant recommended for long-term storage
Custom Synthesis
Custom synthesis services are available for project-specific requirements:
- Milligram-scale requests are not supported
- Milligram → kilogram development is supported starting from 100 g minimum order scale
- Isotope-labeled derivatives (¹³C, ¹⁵N)
- Process optimization and scale-up support
Quality & Documentation
- Certificate of Analysis (COA) with each batch
- HPLC chromatogram, NMR, MS data
- Safety Data Sheet (SDS) available
- Compliant with relevant regulatory standards (REACH / TSCA)
Ordering Information
- Minimum Order Quantity (MOQ): 100 g
- Lead Time:
- Stock items: 3–5 business days
- Custom production: 2–4 weeks
👉 Note: We focus on commercial-scale supply, and do not provide milligram-level quantities.
