Product Details
- Application & Uses:
- Primary Application Area: Pharmaceutical Intermediate.
- Typical Use: N-Benzylguanidine hydrochloride is a key precursor for the synthesis of antihypertensive drugs. Its most significant downstream application is as a starting material for the Active Pharmaceutical Ingredient (API) Guanabenz. Guanabenz is a centrally acting alpha-2 adrenergic agonist used for the treatment of hypertension.
- Role in Synthesis: In the synthesis of Guanabenz, N-benzylguanidine is typically condensed with 2,6-dichlorobenzaldehyde or its derivatives to construct the core pharmacophore of the final drug molecule.
- Research Applications: Because the guanidine group is an important pharmacophore in many bioactive molecules (often mimicking the side chain of arginine), N-benzylguanidine is also used as a chemical probe or building block for developing novel compounds with potential biological activities.
- Regulatory & Safety Notes:
- As a pharmaceutical intermediate, its production and trade may be subject to oversight by relevant national drug regulatory authorities.
- Before handling, the latest Safety Data Sheet (MSDS/SDS) must be read and followed carefully. General precautions include avoiding dust inhalation and direct skin contact. Appropriate Personal Protective Equipment (PPE), such as gloves, safety glasses, and a respirator, should be worn during handling.
- Handling & Packaging:
- Packaging Forms: For research purposes, it is typically supplied in gram to kilogram quantities in bottles. For industrial scale, it may be packed in 25 kg fiber drums with an inner plastic liner.
- Transportation: Shipped as a general chemical. Precautions should be taken to protect it from moisture and damage.
- Market & Other Notes:
- This is a commercially mature and stable fine chemical product. Its market demand is closely tied to the production volume of its downstream APIs, primarily Guanabenz.
- As a well-defined key intermediate, its quality control (e.g., purity, impurity profile) is critical to ensuring the quality of the final API.
